Why is neonate phenobarbital preferred?
Phenobarbital may have a role in the prevention of seizures as well. Phenobarbital (20 mg/kg IV) given within 6 hours of life to term and near-term neonates with hypoxic ischemic encephalopathy, significantly decreased the incidence of neonatal seizures as compared to placebo (8% vs.
What is phenol barbital?
Phenobarbital is a prescription medicine used to treat and prevent the symptoms of seizures, sedation, hypnotics, Insomina and Status Epilepticus. Phenobarbital may be used alone or with other medications.
What is the mechanism of action of phenobarbital?
The primary action of phenobarbital is to enhance the inhibitory actions of gamma-aminobutyric acid (GABA) on neurons. Phenobarbital is metabolized in the liver and renally excreted. Mysoline is ~45% protein-bound. Phenobarbital is rapidly and nearly completely absorbed following oral and intramuscular administration.
How does phenobarbital make you feel?
Phenobarbital may cause you to feel drowsy and unsteady. This often settles down as your body adjusts to the new medicine.
How is phenobarbital administered in neonates?
A loading dose of 15-20 mg/kg body weight given intravenously is recommended. The plasma concentration of phenobarbital will usually reach therapeutic levels (15-30 micrograms/ml) within a few minutes of the injection and will hardly change during the following 48 hours.
Can phenobarbital cause liver damage?
Phenobarbital is a barbiturate that is widely used as a sedative and an antiseizure medication. Phenobarbital has been linked to rare instances of idiosyncratic liver injury that can be severe and even fatal.
What is the adverse effect of the use of phenobarbital?
SIDE EFFECTS: Dizziness, drowsiness, excitation, headache, tiredness, loss of appetite, nausea, or vomiting may occur as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.