What is the CCR2 gene?
UniProtKB/Swiss-Prot Summary for CCR2 Gene Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity).
What is the gene that codes for CCR5?
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3.
What is CCL2 gene?
CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and ERK Signaling.
Do microglia express CCR2?
These novel observations demonstrated that CCR2 is expressed in resident CNS cells such as microglia and neurons, as well as CNS-infiltrating monocytes, in the advanced stage of ALS.
Where is CCR2?
This CCR2 gene is located in the chemokine receptor gene cluster region.
What cell types express CCR2?
CCR2 has been found to be expressed by multiple cell types including monocytes, dendritic cells (DCs), endothelial cells, and cancer cells [51,52,53,54]. CCL2 functions through binding to CCR2, one of 19 members of the human chemokine receptor family .
What is CCL2 and CCR2?
CCL2 (monocyte chemoattractant protein-1, MCP-1) is a potent chemokine for monocytes, and a variety of other immune cells. Its receptor is CCR2, which is expressed at high levels on monocytes. 307. CCL2 is produced by osteoblasts in response to PTH and proinflammatory cytokines.
Is CCL2 pro or anti inflammatory?
In yet another study, it was reported that granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced wound healing in diabetes by upregulating pro-inflammatory cytokines . Interestingly, CCL2 was one of the upregulated pro-inflammatory cytokines.
What is TMEM119?
These results suggest that TMEM119 serves as a reliable microglial marker that discriminates resident microglia from blood-derived macrophages in the human brain.
What are the ligands for CCR2?
CCR2 and Its Ligands in MS, EAE, and TMEV Infection. CCR2 is expressed on Th1 cells, Th17 cells, macrophages, and activated microglia. CCL2 (MCP-1), CCL7 (MCP-3), CCL8, CCL13 (MCP-4), and CCL16 [hemofiltrate CC chemokine (HCC)-4] are known as the CCR2 ligands. CCR2 and its ligands were detected in MS lesions.
What are the gene families for CCR2?
Gene Families for CCR2 Gene HGNC: C-C motif chemokine receptors CD molecules IUPHAR : Chemokine receptors Human Protein Atlas (HPA): CD markers G-protein coupled receptors Predicted membrane proteins Protein Domains for CCR2 Gene InterPro: GPCR_Rhodpsn GPCR_Rhodpsn_7TM Chemokine_rcpt Chemokine_CCR2 Blocks: Chemokine receptor signature
What does CCR2 stand for?
Complete information for CCR2 gene (Protein Coding), C-C Motif Chemokine Receptor 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards – The Human Gene Compendium
Do CCR2 and CX3CR1 play a role in HIV infection?
These findings suggest that CCR2, CX3CR1, RANTES and SDF1 gene variants seem to play an important role in the dynamics of HIV infection and could be used as drug or vaccine targets. A significantly enhanced risk for prostate cancer due to interactions between CCL2 and CCR2 gene variants.
What DNA and viral vectors are available for CCR2?
VectorBuilder Custom and pre-made DNA vectors for CCR2 (ie. gene expression, shRNA knockdown, CRISPR) VectorBuilder Viral vectors for CCR2 (ie. lentivirus, AAV, adenovirus) VectorBuilder Virus packaging for CCR2 (ie. lentivirus, AAV, adenovirus, MMLV, MSCV, baculovirus)