What is monogenic obesity?
Monogenic obesity is defined as obesity resulting from a mutation or deficiency of a single gene.
How are genetics linked to obesity?
Rarely, obesity occurs in families according to a clear inheritance pattern caused by changes in a single gene. The most commonly implicated gene is MC4R, which encodes the melanocortin 4 receptor. Changes in MC4R that diminish its function are found in a small fraction (<5%) of obese people in various ethnic groups.
What is syndromic obesity?
The term “syndromic obesity” is used to describe obese children and adults with cognitive delay, dysmorphic features, organ-specific abnormalities, hyperphagia, and/or other signs of hypothalamic dysfunction (Nature Rev.
What is non syndromic obesity?
Disease definition. A rare genetic disease characterized by early-onset severe obesity due to mutations in single genes acting on the development and function of the hypothalamus or the leptin-melanocortin pathway, leading to disruption of energy homeostasis and endocrine dysfunction.
Is obesity hereditary or environmental?
Obesity is determined by the genetics as well as obesogenic environment [4-5]. It was first studied in 1994 that Ob gene and leptin play an important role in determining the body weight of an individual .
What is Bardet-Biedl syndrome?
Bardet-Biedl syndrome (BBS) is a genetic condition that impacts multiple body systems. It is classically defined by six features. Patients with BBS can experience problems with obesity, specifically with fat deposition along the abdomen. They often also suffer from intellectual impairments.
Is leptin dominant or recessive?
This condition is inherited in an autosomal recessive pattern , which means both copies of the gene in each cell have mutations.