What is a lipogranuloma?
A lipogranuloma is an inflammatory reactive process associated with exogenous or endogenous lipids, and it’s occurrence in the breast has rarely been reported. Osseous metaplasia, which is used to describe bone formation in abnormal locations, can develop from several conditions such as trauma or a tumor.
What is sclerosing Lipogranuloma?
Sclerosing lipogranuloma (SLG) is a granulomatous inflammation with marked sclerosing response to the fatty tissue (1). It may occur in any part of the body but is frequently reported in the male external genitalia (2).
What is lipogranuloma of oil secreting gland of the eyelid?
Chalazion is a lipogranuloma of one of the meibomian glands of the tarsal plate. They arise relatively rapidly over a period of a few days, often with inflammation and discomfort. They can progress to form a chronic pea-sized, firm nodule in the lid (Figure 13).
What is histopathological granuloma?
Abstract. Granulomatous inflammation is a histologic pattern of tissue reaction which appears following cell injury. Granulomatous inflammation is caused by a variety of conditions including infection, autoimmune, toxic, allergic, drug, and neoplastic conditions.
What causes meibomian glands to clog?
Poor eyelid hygiene, bad nutrition, and activities that decrease your blink rate result in clogged meibomian glands. The technology era has contributed to the increase in dry eye in all ages. The eyelid margin consists of skin, meibomian gland openings and eyelashes.
How do you get rid of an oil gland on your eyelid?
Warm compresses: Wet a clean washcloth with warm water. Hold it on the affected eye for 15 minutes. Do this at least three times a day to help the blocked oil gland open up. Massage: Gently massage the eyelid a few times a day.
What causes granulomatous?
Granulomas seem to be a defensive mechanism that triggers the body to “wall off” foreign invaders such as bacteria or fungi to keep them from spreading. Common causes include an inflammatory condition called sarcoidosis and infections such as histoplasmosis or tuberculosis.
How do you treat granulomatous disease?
Treatment. People with CGD take lifelong regimens of antibiotics and antifungals to prevent infections. Injections with interferon gamma, a protein that improves the activity of phagocytes, also may help reduce the number of severe infections. Abscesses need aggressive care that may include surgery.
What causes a Caseating granuloma?
Caseating granulomas are formed by infections, such as tuberculosis and fungal infections. Noncaseating granulomas may be formed by an inflammatory condition (e.g., sarcoidosis and Crohn disease), vasculitis, and exposure to foreign objects. Formation of granulomas is characteristic of certain diseases.
What is the best treatment for meibomian gland dysfunction?
Topical azithromycin has been shown to be a potentially effective and well tolerated treatment for meibomian gland dysfunction in recent studies. Topical azithromycin therapy could lead to clinical control or relief of symptoms and signs of MGD, as well as improvement in lipid behaviors of meibomian gland secretion.
What is the histopathology of sclerosing lipogranuloma?
In sclerosing lipogranuloma, the histopathology shows fat necrosis, histiocytes, giant cells with extensive fibrosis and hyalinization. There are polymorphous vacuoles of the foreign material and pseudocysts where there is more extensive accumulation of material (figures 1,2).
What is lipogranulomatous lymphadenopathy?
Lipogranulomatous lymphadenopathy is a rare pathologic condition and may be responsible for smears with numerous MGC. This entity should be considered when evaluating lymph node aspirates from patients with neoplasia, particularly that with a giant cell component.
What is lipogranuloma and what is its microscopy?
Microscopically, lipogranuloma consists of lipid vacuoles embedded in a sclerotic stroma, usually accompanied by a histiocytic or foreign body granulomatous infiltrate with or without eosinophils ( Fig. 15.65 ). 592 CD68 staining is strongly positive in multinucleated giant cells and epithelioid histiocytic cells.
What is lipogranuloma (paraffinoma)?
Lipogranuloma (also known as paraffinoma, sclerosing lipogranuloma, and Tancho’s nodules) may involve the penile or scrotal skin.