Table of Contents
Are NOD SCID mice diabetic?
As outlined in a recent post, NOD-scid mice (NOD. CB17-Prkdcscid/J), because they are B and T cell-deficient, do not develop diabetes.
What does nod stand for in mice?
NOD, also known more fully as NOD/ShiLtJ or NOD/LtJ, is an inbred strain of mouse that serves as a very popular model for diabetes research (“NOD” stands for “Non-Obese Diabetic”).
How are NOD mice generated?
Starting with the 20th generation of mt mice, Makino established the first generation of the NOD mouse breeding program using several female mt mice to start brother-sister matings under specific pathogen–free (SPF) conditions. These female mice were confirmed insulitis positive.
Why do NOD mice get diabetes?
Non-obese diabetic or NOD mice, like biobreeding rats, are used as an animal model for type 1 diabetes. Diabetes develops in NOD mice as a result of insulitis, a leukocytic infiltrate of the pancreatic islets. The onset of diabetes is associated with a moderate glycosuria and a non-fasting hyperglycemia.
Do SCID mice have macrophages?
Mice bearing the SCID mutation are devoid of T and B cells but retain elements of the innate immune system including natural killer (NK) cells, macrophages, granulocytes and complement proteins.
What does NPD stand for?
Narcissistic personality disorder — one of several types of personality disorders — is a mental condition in which people have an inflated sense of their own importance, a deep need for excessive attention and admiration, troubled relationships, and a lack of empathy for others.
What is glyburide 5 mg used for?
Glyburide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes.
Do SCID mice have neutrophils?
Neutrophils and monocytes constitute most of the remaining mouse immune cells detectable in peripheral blood. Dendritic cells and macrophages are also present in the mouse, although they are defective because of alleles in the NOD/ShiLt genetic background.