What kind of inhibitor is diisopropyl fluorophosphate?
Diisopropylfluorophosphate (DFP) is a potent acetylcholinesterase inhibitor commonly used in toxicological studies as an organophosphorus nerve agent surrogate.
What is affected by diisopropyl fluorophosphate?
Acute exposure to diisopropyl fluorophosphate (DFP) causes irreversible inhibition of acetylcholinesterase activity, leading to various behavioral and autonomic sequelae including hypothermia, reduced motor activity, and other neurological dysfunctions.
How does DFP inhibit serine protease?
Diisopropyl fluorophosphate (DFP) is an irreversible serine protease inhibitor. Its hydrophobic nature and low molecular weight allow it to permeate intact cells and intracellular granules to prevent proteolysis before cellular barriers are disrupted by homogenization or detergent .
What is diisopropyl fluorophosphate used for?
Diisopropyl fluorophosphate is a parasympathomimetic drug irreversible anti-cholinesterase and has been used in ophthalmology as a miotic agent in treatment of chronic glaucoma, as a miotic in veterinary medicine, and as an experimental agent in neuroscience because of its acetylcholinesterase inhibitory properties and …
What are the effects of sarin gas?
Exposure to large doses of sarin by any route may result in the following harmful health effects: Loss of consciousness. Convulsions. Paralysis.
What is the function of diisopropyl fluorophosphate?
What is Isoflurophate used for?
Isoflurophate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Isoflurophate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
What does serine protease inhibitor do?
Serine protease inhibitors (SPI) are a superfamily of the conserved proteins able to inhibit enzymatic activity of serine proteases and play a major role in complement activation, blood coagulation, inflammation, and fibrinolysis (Gettins, 2002; Molehin et al., 2012).