What is Wuchereria bancrofti and Brugia malayi?
There are three different filarial species that can cause lymphatic filariasis in humans. Most of the infections worldwide are caused by Wuchereria bancrofti. In Asia, the disease can also be caused by Brugia malayi and Brugia timori. The infection spreads from person to person by mosquito bites.
How will you distinguish microfilariae of Wuchereria bancrofti from that of Brugia malayi?
malayi is transmitted by Mansonia mosquitos. Since these mosquitos feed primarily during the day, B. malayi microfilaria can be found in the blood during the day, while microfilaria of W. bancrofti is found at high levels at night.
What is the vector of Brugia malayi?
The typical vector for Brugia malayi filariasis are mosquito species from the genera Mansonia and Aedes. During a blood meal, an infected mosquito introduces third-stage filarial larvae onto the skin of the human host, where they penetrate into the bite wound .
What is Brugia malayi diagnosis?
B. malayi is one of the causative agents of lymphatic filariasis, a condition marked by infection and swelling of the lymphatic system. The disease is primarily caused by the presence of worms in the lymphatic vessels and the resulting inflammatory response of the host.
How do the microfilariae of Onchocerca volvulus differ from those of other filarial?
Structure. Adult Onchocerca may be up to 60 cm long, but are usually coiled in subcutaneous nodules. The microfilariae are slightly smaller than those of W bancrofti and B malayi and differ from them in lacking a sheath, having a different nuclear arrangement, and not usually being found in the blood.
How do you differentiate B. malayi and W bancrofti?
malayi have an indentation around their bases which is absent in W. bancrofti. This is the most useful distinguishing feature and easily recognizable. The oral opening and the cephalic papillae in both the species are similar and not useful for differentiation.
Where is Brugia malayi in human body?
Lymphadenitis. Lymphadenitis, the swelling of the lymph nodes, is a commonly recognized symptom of many diseases. It is an early manifestation of filariasis, usually occurs in the inguinal area during B. malayi infection and can occur before the worms mature.
Is Brugia malayi sheathed?
Microfilariae of Brugia malayi are sheathed and in stained blood smears measure 175—230 µm.
How is Brugia malayi treated?
As to the treatment of B. malayi infection, diethylcarbamazine has been found to reduce the microfilaria count and to kill the adult worms; the severe febrile reactions of microfilaria carriers to the initial doses of this drug may be reduced by administration of the steroid prednisolone.