What is Thiotepa injection for?
Thiotepa is used to treat certain types of ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), breast, and bladder cancer. It is also used to treat malignant effusions (a condition when fluid collects in the lungs or around the heart) that are caused by cancerous tumors.
What is intrathecal chemotherapy?
Intrathecal chemotherapy is when chemotherapy is given into the fluid around the spinal cord during a lumbar puncture. A doctor or specially trained nurse will do the lumbar puncture. Your doctor or nurse will usually give you a local anaesthetic first.
What is the most serious complication of chemotherapy?
Cardiovascular effects can be among the most serious adverse events resulting from chemotherapy, and can occur early or late during the treatment. Cardiotoxicity can be mild, consisting of blood pressure changes, to more severe, such as myocardial infarction and heart failure.
What type of drug is thiotepa?
OrganothiophosphateThiotepa / Classification
How is thiotepa administered?
Thiotepa may be administered by intravenous, intramuscular, intrapleural, intraperitoneal, intrapericardial or intratumour injection, or by intravesical instillation. Thiotepa may be given rapidly intravenously in doses of 0.3–0.4 mg/kg at intervals of 1–4 weeks.
How is intrathecal chemotherapy performed?
A healthcare professional will administer intrathecal chemotherapy by injecting it into the spinal canal during a lumbar puncture. They may also administer it through a plastic insert called an Ommaya reservoir, which sits under the scalp.
Is cyclophosphamide a strong chemotherapy?
Cyclophosphamide is one of a number of medications first developed as a chemotherapy drug (a medication used in the treatment of cancer). It was discovered that — in addition to its usefulness in cancer — cyclophosphamide also has a significant ability to suppress the immune system.
What cancers is cyclophosphamide used for?
Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).
What are the signs that chemo is not working?
Here are some signs that chemotherapy may not be working as well as expected: tumors aren’t shrinking. new tumors keep forming. cancer is spreading to new areas.
What types of cancer can thiotepa be used for?
Malignant pleural effusion, malignant pericardial effusion, and malignant peritoneal effusion. Ovarian cancer. Thiotepa is also being studied in the treatment of other types of cancer and as part of a regimen to prepare patients for bone marrow and stem cell transplants.
How long does thiotepa chemotherapy last?
Thiotepa is usually given in combination with other chemotherapy drugs. It is given over several days before you have a stem cell or bone marrow transplant. It is given either every 12 or 24 hours. Treatment can last for up to 5 days.
How does thiotepa work?
Thiotepa is a type of drug called an alkylating agent. It works by sticking to 1 of the cancer cell’s DNA strands. Then the cell can’t divide into 2 new cells. The DNA is the genetic code that is in the heart of all animal and plant cells.
Who will I See for thiotepa treatment?
Thiotepa can be given in combination with other cancer drugs. During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. This is who we mean when we mention doctor, nurse or pharmacist in this information.