What is the function of angiostatin?
Angiostatin is such a specific angiogenesis inhibitor produced by tumors. It inhibits primary and metastatic tumor growth by blocking tumor angiogenesis. Having demonstrated potent antitumor activity in animal studies, angiostatin is now in clinical trials for human cancer therapy.
What do angiostatin and endostatin do?
Angiostatin and endostatin are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis in vivo and tumor growth in mice.
Where is angiostatin produced?
Interestingly, angiostatin is generated endogenously by subcutaneous Lewis lung carcinomas in mice, inhibiting the growth of spontaneously occurring pulmonary metastases (O’Reilly et al., 1994). This conversion of plasminogen to angiostatin is catalyzed by macrophage-derived metalloelastase (Dong et al., 1997).
Where do angiostatin and endostatin come from?
Recently, angiostatin and endostatin became widely available to the research community in recombinant forms, expressed and purified from Pichia pastoris. The increased availability of these proteins will likely facilitate tumor angiogenesis research.
What type of substances are angiostatin and endostatin?
Angiostatin and endostatin: endogenous inhibitors of tumor growth.
What kind of inhibitor is endostatin?
Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).
Is angiostatin FDA approved?
Endostatin has been approved by the US Food and Drug Administration (FDA) for the treatment of NV-related cancer; thus, it may be an additional drug that can be added to anti-VEGF therapy to treat corneal NV- and lymphangiogenesis-related disorders.
What is a angiogenesis in medical terms?
(AN-jee-oh-JEH-neh-sis) Blood vessel formation. Tumor angiogenesis is the growth of new blood vessels that tumors need to grow.
Is endostatin still used today?
Endostatin is currently being studied as part of cancer research. Prior results indicated that endostatin can be beneficial in combinations with other medicines, but endostatin alone gave no significant improvements in tumor/disease progression.
What was the name of the doctor who discovered endostatin?
NARRATOR: This is Children’s Hospital in Boston, an important battlefield in the war against cancer, and where Endostatin was discovered in the laboratory of Dr. Judah Folkman.