What is the difference between infusion reaction and hypersensitivity reaction?
Hypersensitivity reactions may also be non-IgE mediated, but the manifestations are identical. An infusion reaction is a type of hypersensitivity reaction that develops during or shortly after administration of a drug.
Which chemotherapy drug has the greatest risk of cumulative hypersensitivity reactions?
Patients who receive first-line platinum-based chemotherapy, and then are treated again with a platinum agent at the time of relapse, are at the greatest risk of experiencing hypersensitivity.
Why does rituximab cause infusion reaction?
Official Answer. Rituximab infusion reactions are caused primarily by cytokine release in the body. Cytokines are immune system proteins in the body that help to fight infections but can cause an inflammatory response.
Can carboplatin cause a rash?
Severity of carboplatin hypersensitivity varies from a mild rash to life-threatening reactions. With an increase in the number of cycles the risk of hypersensitivity reactions increase, which jeopardizes the use of this highly effective drug in a significant proportion of patients.
What does hypersensitivity mean in medical terms?
Medical Definition of hypersensitive 1 : excessively or abnormally sensitive. 2 : abnormally susceptible physiologically to a specific agent (as a drug or antigen)
What is carboplatin desensitization?
Carboplatin desensitization prevents life-threatening HSRs and promotes the successful completion of planned chemotherapy. Methods: Since January 2010, carboplatin desensitization was performed at our institution.
What causes the most infusion reactions to rituximab?
Cytokine release is believed to be partially responsible for most rituximab-associated infusion reactions, and levels of inflamma- tory cytokines have been shown to increase significantly during the administration of rituximab (Byrd et al., 2001).
Why is Benadryl given during chemo?
RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy.
What is the difference between cisplatin and carboplatin?
Cisplatin, cis-[Pt(NH3)2Cl2], is a widely used antitumor agent for the treatment of testicular and ovarian cancers. Carboplatin is used extensively for small cell, non small cell lung cancer and ovarian cancer. Oxaliplatin has recently been approved in the US for treatment of colorectal cancer.
What is the mechanism of action of carboplatin as anticancer?
Mechanism of action Carboplatin undergoes activation inside cells and forms reactive platinum complexes that cause the intra- and inter-strand cross-linkage of DNA molecules within the cell.
Will you have chest pain with carboplatin?
Summary: Chest pain is found among people who take Carboplatin, especially for people who are female, 60+ old, have been taking the drug for < 1 month. The phase IV clinical study analyzes which people take Carboplatin and have Chest pain. It is created by eHealthMe based on reports of 76,744 people who have side effects when taking Carboplatin from the FDA, and is updated regularly.
Does carboplatin cause heart failure?
They are used to treat a variety of cancers, including leukemia, lymphoma, and cancers of the breast, uterus, ovary, and lung. At high cumulative doses, these drugs can weaken the left ventricle, the heart’s main pumping chamber, leading to heart failure.