What is the 5-HTTLPR genotype?
The 5-HTTLPR is a repeat polymorphism with long (L) and short (S) alleles. The S allele is associated with lower 5-HTT expression and function, as well as anxiety and negative mood in healthy individuals.
What does the 5-HTTLPR gene do?
The 5-HTTLPR is a polymorphism in the promoter region of the serotonin transporter encoding gene, whose two different variants (short and long) have differential effects on the way the serotonin transporter carries out its task, with the short (S) version transporting significantly less serotonin back to the …
What has been found for individuals who inherit two short alleles of the 5-HTTLPR gene?
All humans inherit a copy of this gene variant from each parent. Study participants with two short 5-HTTLPR alleles were found to be most unhappy in their marriages when there was a lot of negative emotion, such as anger and contempt, and most happy when there was positive emotion, such as humor and affection.
What did Caspi et al find?
Caspi et al concluded that people with one or two copies of this short allele exhibited more depressive symptoms, diagnosable depression and suicidal ideation in relation to stressful life-events than individuals who carried the long allele of 5-HTT.
What is the 5-HTT gene psychology?
The 5-HTT gene is responsible for regulating the chemical serotonin, which helps transmit messages in the brain. The people who showed a greater fear response during an experiment had a variation in the gene. This variation is linked to increasing the regulation of serotonin levels in the brain.
What does 5-HTT do?
The serotonin transporter protein (5-HTT/SLC6A4) transports the neurotransmitter serotonin from synapses to presynaptic neurons. It seems to be an important component in the physiological response to cocaine and amphetamines.
What research method did Caspi use?
Method: The researchers used an opportunity sample from a cohort of participants who were part of another longitudinal study. There were 847 participants of 26 years old and they were split into three groups, depending on the length of the alleles on their 5HTT transporter gene.
What type of study was Caspi?
Avshalom Caspi | |
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Scientific career | |
Fields | Psychology |
Institutions | Duke University Institute of Psychiatry, Psychology and Neuroscience at King’s College London |
Thesis | Moving against and moving away: life-course patterns of explosive and withdrawn children (1986) |
What is HTR2A gene?
HTR2A (5-Hydroxytryptamine Receptor 2A) is a Protein Coding gene. Diseases associated with HTR2A include Major Depressive Disorder and Obsessive-Compulsive Disorder. Among its related pathways are Peptide ligand-binding receptors and CREB Pathway.
What causes lack of serotonin?
a poor diet. chronic stress. a lack of exposure to natural light. inadequate exercise levels.