What is oral hydrocortisone used for?
Hydrocortisone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, and ulcerative colitis.
How is hydrocortisone metabolized?
Hydrocortisone is metabolised to 6-beta hydrocortisol via CYP3A, 5-beta tetrahydrocortisol via 3-oxo-5-beta-steroid 4-dehydrogenase, 5-alpha tetrahydrocortisol via 3-oxo-5-alpha-steroid 4-dehydrogenase 2, cortisone via Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticosteroid 11-beta-dehydrogenase isozyme 2.
What are the side effects of hydrocortisone IV?
Hydrocortisone injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache.
- dizziness.
- slowed healing of cuts and bruises.
- acne.
- thin, fragile, or dry skin.
- red or purple blotches or lines under the skin.
- skin depressions at the injection site.
How quickly does IV hydrocortisone work?
A clinical effect is seen in two to four hours, and it persists for up to eight hours after intravenous injection. The same dose can be given by intramuscular injection, but the response is likely to be less rapid, especially in shock.
Can you overdose on hydrocortisone?
Taking too many hydrocortisone tablets as a one-off is unlikely to harm you. If you’re worried, talk to your doctor or pharmacist. If you take too much hydrocortisone for more than a few days, it could harm your health. Talk to your doctor as soon as possible.
Is hydrocortisone a painkiller?
Hydrocortisone is a steroid (corticosteroid) medicine. It works by calming down your body’s immune response to reduce pain, itching and swelling (inflammation). It can also be used as hormone replacement for people who do not have enough of the natural stress hormone, cortisol.
How are corticosteroids metabolised?
Corticosteroids are metabolized through enzymatic transformations that diminish their physiologic activity and increase water solubility to enhance their urinary excretion. The majority of serum cortisol is reduced to dihydrocortisol and then to tetrahydrocortisol, which is then conjugated to glucuronic acid.
Where is hydrocortisone produced in the body?
Hydrocortisone (HC) is a steroid hormone produced by the adrenal gland.
Can you put on too much hydrocortisone cream?
Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time.