What is Kolliphor HS 15?
Kolliphor® HS 15 is a nonionic solubilizer and emulsifying agent obtained by reacting. 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid. Description Kolliphor® HS 15 is a yellowish white paste at room temperature that becomes liquid at approx. 30 °C.
What is solutol HS15?
Solutol HS15 (polyoxyethylene esters of 12-hydroxystearic acid) is an amphiphilic nonionic surfactant made by fusing fatty acids and end-capped methoxy polyethylene glycol (mPEG) and demonstrated biocompatibility . From: Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer, 2019.
What is solutol used for?
Introduction. Kolliphor® HS 15 (formerly regarded as Solutol® HS 15) a non-ionic surfactant, has been used as a solubilizer in parenteral and oral formulations for over several decades.
What is Cremophor used for?
Cremophor EL (CrEL) is a formulation vehicle used to improve solubility of various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). In contrast to earlier reports, CrEL is not an inert vehicle, but exerts a range of biological effects, some of which have important clinical implications.
How does Soluplus dissolve?
Soluplus® can effectively be layered over beads, spheres, mini-tablets or other fluidized granules using a conventional fluid bed coater. Similar to spray drying, Soluplus® should first be dissolved together with poorly water-soluble API in a mutually effective solvent (e.g. ethanol, methanol, acetone).
What is PEG 40 hydrogenated castor oil used for?
PEG 40 hydrogenated castor oil is used in cosmetics as a solubiliser, emulsifier, surfactant and emollient. It is derived from Castor oil and is useful in producing products that disperse in water whilst offering good moisturising properties.
Is Cremophor EL soluble in water?
Cremophor EL (CrEL) is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). In contrast to earlier reports, CrEL is not an inert vehicle, but exerts a range of biological effects, some of which have important clinical implications.
What drugs contain Cremophor?
Cremophor is a synthetic, nonionic surfactant made by reacting castor oil with ethylene oxide. It is widely used for water-insoluble drugs, including paclitaxel, cyclosporine, propofol, althesin, propanidid, and vitamin supplements.