What is cilastatin used for?
Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections.
What does cilastatin do for imipenem?
Imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.
How do you use Tienam?
Method of administration TIENAM is to be reconstituted and further diluted (see section 6.2, 6.3 and 6.6) prior to administration. Each dose of ≤500 mg/500 mg should be given by intravenous infusion over 20 to 30 minutes. Each dose >500 mg/500 mg should be infused over 40 to 60 minutes.
Why are carbapenems administered with cilastatin?
Imipenem is hydrolyzed by renal tubular dipeptidase. Imipenem is therefore always combined with cilastatin, which inhibits this breakdown. Other carbapenems do not require coadministration with cilastatin because they are not metabolized by dipeptidase. Doses must be reduced in patients with renal dysfunction.
Is Recarbrio an antibiotic?
Recarbrio is an antibiotic for treating adults with the following infections: lung infections caught in hospital (hospital-acquired pneumonia), including ventilator-associated pneumonia (pneumonia caught while on a ventilator, which is a machine that helps a patient to breathe);
Can amikacin damage kidneys?
Amikacin can harm your kidneys, and may also cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines. Tell your doctor about all your medical conditions and all the medicines you are using. If you need surgery, tell the surgeon ahead of time that you are using amikacin.
What is the pharmacology of cilastatin?
8.1 Pharmacology. Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Renal Dehydropeptidase degrades the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.
Why is cilastatin used in combination with imipenem?
Since the antibiotic, imipenem, is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastatin is used in combination with imipenem to prevent its metabolism.
What is the volume of cilastatin in urine?
Cilastatin is a Renal Dehydropeptidase Inhibitor. The mechanism of action of cilastatin is as a Dipeptidase Inhibitor. Cilastatin is reported by official FDA labeling to be 70% excreted in the urine, however published literature has reported values as high as 98%. [A181271] Cilastatin has a volume of distribution of 14.6-20.1L. [A181271]
Does cilastatin interact with captopril or cefazolin?
The excretion of Captopril can be decreased when combined with Cilastatin. The excretion of Cefaclor can be decreased when combined with Cilastatin. The excretion of Cefazolin can be decreased when combined with Cilastatin. The excretion of Cefdinir can be decreased when combined with Cilastatin.