What happens if you overdose on benzonatate?

What happens if you overdose on benzonatate?

Individuals who experience overdose of benzonatate may exhibit restlessness, tremors, convulsions, coma, and cardiac arrest. Signs and symptoms of overdose can occur rapidly after ingestion (within 15-20 minutes). Deaths in children have been reported within hours of the accidental ingestion.

How long do benzonatate side effects last?

Central nervous system (CNS) problems, such as headache, confusion, visual hallucinations, and dizziness, occur fairly early (within an hour) after taking a dose of benzonatate. These rapid or early side effects generally fade as the drug wears off in three to eight hours.

How is benzonatate metabolized?

Benzonatate is hydrolyzed by plasma butyrylcholinesterase (BChE) to the metabolite 4-(butylamino)benzoic acid (BABA) as well as polyethylene glycol monomethyl esters. Like many other local anesthetic esters, the hydrolysis of the parent compound is rapid.

What drugs should not be taken with benzonatate?

Benzonatate may interact with other medications that cause drowsiness including, cough and cold medications, antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotics, or psychiatric medicines.

How many mg of benzonatate is fatal?

Overdosage resulting in death may occur in adults. Do not exceed a single dose of 200 mg and a total daily dose of 600 mg. If you miss a dose of benzonatate, skip that dose and take the next dose at the next scheduled time.

How much benzonatate does it take to overdose?

In children, accidental ingestion has been reported to lead to overdose symptoms within 15-20 minutes and death within 1 hour. The benzonatate labeling states that patients should not exceed a single dose of 200mg and total daily dosage of 600mg.

Can I take 200 mg of benzonatate?

Adults and children 10 years of age and older—100 milligrams (mg) three times a day. Do not take more than 200 mg at one time or more than 600 mg per day. Children younger than 10 years of age—Use is not recommended.

What are the side effects of benzonatate 100 mg?

Benzonatate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea.
• constipation.
• drowsiness.
• headache.
• dizziness.
• stuffy nose.
• feeling chilly.
• burning in the eyes.

What happens if you overdose on tessalon Perles?

An overdose of Tessalon Perles can be fatal, especially to a child. Accidental death has occurred in children under 10 years old. Overdose symptoms may include tremors, feeling restless, seizure (convulsions), slow heart rate, weak pulse, fainting, and slow breathing (breathing may stop).

Can I take 200 mg benzonatate?

For oral dosage form (capsules): For cough: Adults and children 10 years of age and older—100 milligrams (mg) three times a day. Do not take more than 200 mg at one time or more than 600 mg per day.

How much benzonatate is lethal?

Is benzonatate a risk for overdose in children?

CONCLUSIONS Ingestion of benzonatate, a widely prescribed antitussive, may pose a risk to patients due to the potential for rapid development of life-threatening adverse events and limited treatment options in the overdose setting, not only in children but also in adults. Rational prescribing and patient education are needed.

What is the maximum daily dosage for Benzonatate?

Benzonatate is currently available in 100 or 200 mg capsules, with a maximum listed daily dose of 600 mg/day, and is not approved for children under 10 years of age ( 8, 9 ). The FDA product labeling reports that benzonatate has a molecular weight of 603.7 g/mol with a side chain of nine ethoxy units.

What are the side effects of benzonatate?

Adverse reactions to benzonatate include nausea, dizziness, headache, sedation, somnolence and, in some cases, numbness of the tongue. Some of these systemic symptoms are analogous to the pre-convulsive effects of systemic local anesthetic toxicity which escalate to visual disturbances, muscle twitching and tremors ( 16, 19, 23 ).

Is benzonatate a nonnarcotic?

BACKGROUND Benzonatate is one of the most widely prescribed nonnarcotic antitussives to relieve cough symptoms. As a structurally similar agent to other local anesthetics, including tetracaine and procaine, the risk to the public is not fully appreciated.