What does estrogen and progesterone receptor negative mean?
If breast cancer cells have estrogen receptors, the cancer is called ER-positive breast cancer. If breast cancer cells have progesterone receptors, the cancer is called PR-positive breast cancer. If the cells do not have either of these 2 receptors, the cancer is called ER/PR-negative.
What does estrogen receptor negative mean?
Describes cells that do not have a protein that binds to the hormone estrogen. Cancer cells that are estrogen receptor negative do not need estrogen to grow. This means that they will keep growing when estrogen is not present and do not stop growing when treated with substances that block estrogen from binding.
What does progesterone receptor negative mean?
Cancer cells that are progesterone receptor negative do not need progesterone to grow. This means that they will keep growing when progesterone is not present and do not stop growing when treated with substances that block progesterone from binding. Also called PR negative.
Is it better to be HER2-negative?
In normal cells, HER2 helps control cell growth. Cancer cells that are HER2 negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface.
Does HER2-negative mean chemotherapy?
People with HER2-negative breast cancer may need surgery, chemotherapy, radiation therapy, bisphosphonates, or a combination of these treatments.
Is triple negative aggressive?
Triple-negative breast cancer (TNBC) is considered an aggressive cancer because it grows quickly, is more likely to have spread at the time it’s found, and is more likely to come back after treatment than other types of breast cancer.
What is the difference between estrogen-receptor-positive and progesterone-receptors-positive?
A cancer is estrogen-receptor-positive if it has receptors for the hormone estrogen. A cancer is progesterone-receptor-positive if it has receptors for the hormone progesterone. both estrogen-receptor-positive and progesterone-receptor-positive
What is hormone receptor negative breast cancer?
Hormone receptor-negative (or hormone-negative) breast cancers have no estrogen or progesterone receptors. Treatment with hormone therapy drugs is not helpful for these cancers. These cancers tend to grow faster than hormone receptor-positive cancers. If they come back after treatment, it’s often in the first few years.
How common are estrogen-receptor-negative and progesterone receptor-negative breast cancers?
19.0% of the breast cancers were estrogen-receptor-negative and progesterone-receptor-negative 12.2% of the breast cancers were estrogen-receptor-positive and progesterone-receptor-negative 1.6% of the breast cancers were estrogen-receptor-negative and progesterone-receptor-positive
What does it mean to be hormone receptor positive?
Cancers are called hormone receptor-positive or hormone receptor-negative based on whether or not they have these receptors (proteins). Knowing the hormone receptor status is important in deciding treatment options. Ask your doctor about your hormone receptor status and what it means for you. What are estrogen and progesterone receptors?