What does a high alkaline phosphatase indicate?
High alkaline phosphatase (ALP) levels may indicate that there’s damage to your liver or that you have a type of bone disorder. Liver damage creates a different type of ALP than bone disorders do.
What is considered a dangerously high alkaline phosphatase level?
Values above 130 U/L are usually considered to be high. High levels of ALP in the blood may indicate bone, liver, or bile duct disease.
What causes transient Hyperphosphatasemia?
A possible etiology for the condition is proposed involving (a) increased synthesis of alkaline phosphatase, mediated by vitamin D metabolites, and (b) decreased hepatic clearance caused by the high sialic acid content and exacerbated in some cases by the effects of some drugs on the liver.
Is alkaline phosphatase a tumor marker?
Serum ALP was found to be a valuable tumor marker with high specificity in osteosarcoma.
Why is Alk Phos elevated in neonates?
Background: Elevated serum alkaline phosphatase (ALP) in infants with intestinal failure (IF) can be due to parenteral nutrition-associated liver disease (PNALD) or metabolic bone disease (MBD).
What is benign transient Hyperphosphatasemia?
Transient Hyperphosphatasemia (TH) is a benign condition in which serum alkaline phosphatase (ALP) is transiently elevated in the absence of other systemic diseases. It mainly occurs in infants and children and very rarely seen in adults.
What are alkaline phosphatase levels?
The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (µkat/L). Normal values may vary slightly from laboratory to laboratory. They also can vary with age and sex. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women.
What is osteopenia prematurity?
Osteopenia of prematurity is a metabolic bone disease of premature infants with birth weight < 1500 g and gestational age < 32 weeks. Sub-optimal bone matrix, poor skeletal support and an increased risk of fractures characterized the disease.