What does 5-HTTLPR stand for?
5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat polymorphic region in SLC6A4, the gene that codes for the serotonin transporter. Since the polymorphism was identified in the middle of the 1990s, it has been extensively investigated, e.g., in connection with neuropsychiatric disorders.
What is the HTR2A gene?
HTR2A (5-Hydroxytryptamine Receptor 2A) is a Protein Coding gene. Diseases associated with HTR2A include Major Depressive Disorder and Obsessive-Compulsive Disorder. Among its related pathways are Peptide ligand-binding receptors and CREB Pathway.
How quickly will 5-HTP work?
Use for at least two weeks to notice a beneficial effect ( 28 ). Migraines: 100–200 mg, 2–3 times per day with meals. Use for two to three weeks to notice a beneficial effect ( 33 ).
Does 5-HTP lower blood pressure?
No significant side effects of treatment were observed. The reduction of blood pressure accompanying treatment with L-5-hydroxytryptophan suggests that at least a portion of the antihypertensive effect of L-tryptophan is mediated via serotonin.
What do serotonin transporters do?
Serotonin transporters (SERTs) are largely recognized for one aspect of their function—to transport serotonin back into the presynaptic terminal after its release. Another aspect of their function, however, may be to generate currents large enough to have physiological consequences.
What are the 5 genotypes of 5-HTTLPR?
Subjects were classified into five genotypes: S/S, S/L, L/L, S/XL, and L/XL (no respondents were homozygous for the XL allele). The genotype frequencies are in Hardy-Weinberg equilibrium (χ2=2.59, df=3, p~0.46). Analytic Strategy Genotype information for 5-HTTLPR is available for 1,019 of the 1,036 medical exam participants.
Does the 5-HTT genotype modify stress?
Other support for effect modification of stress by 5-HTT genotype comes from neuroimaging studies, where amygdala hyperreactivity in response to fearful stimuli has been reported in individuals with ‘s’ alleles compared with ‘l/l’ homozygous individuals in a number of studies (for example, see Hariri et al, 2005 ).
How do I view genotype frequencies?
Genotype frequencies can be viewed either as a table or as a bar chart (several bar charts if >5 alleles). Frequencies for a subset of genotypes (e.g. all genotypes with allele p) can also be viewed by using the drop-down menu.
How do you use Punnett square to find the genotype?
The allele combinations along the top and sides become labels for rows and columns within the square. Complete the genotypes in the square by filling it in with the alleles from each parent. Since all allele combinations are equally likely to occur, a Punnett Square predicts the probability of a cross producing each genotype.