How rare is collagenous sprue?
Collagenous sprue is a rare disease entity, with only about 60 sporadic cases reported worldwide since it was first described in 1947.
What is collagenous gastritis?
Collagenous gastritis is a rare histopathological disorder characterized by thick subepithelial collagen bands (>10 μm) associated with an inflammatory infiltrate of the gastric mucosa. There is mixed chronic inflammation in the lamina propria and surface epithelial damage of varying degree.
What is collagenous Duodenitis?
Collagenous duodenitis is often described as sharing histopathologic features of collagenous sprue. However, our patient had collagen banding with preserved duodenal villous architecture in the absence of celiac disease.
What is refractory sprue?
Affecting no more than 1 in 50 people with celiac disease, refractory sprue is defined as malabsorptive symptoms and villous atrophy that persist or recur after six to 12 months on a strict gluten-free diet. Refractory disease is divided into two types based on flow cytometric analysis of small bowel biopsies.
What causes collagenous sprue?
Collagenous sprue is a small bowel mucosal lesion that has been historically associated with persistent diarrhea, progressive weight loss and severe malabsorption causing multiple nutrient deficiencies. A severe to variably severe mucosal lesion with distinct subepithelial collagen deposits occurs.
What is collagenous colitis?
Collagenous colitis (CC) is a condition that affects your large intestine. It leads to episodes of watery diarrhea and belly pain. Your large intestine is part of your digestive (gastrointestinal or GI) tract. The GI tract goes from your mouth all the way to your rectal opening.
What is collagenous sprue?
Is collagenous gastritis and autoimmune disease?
Adult collagenous gastritis is also associated with autoimmune diseases such as Sjögren syndrome , lymphocytic gastritis, lymphocytic colitis, and ulcerative colitis. Other signs and symptoms of CG may include nausea and vomiting, weight loss, abdominal distention, and gastrointestinal bleeding.
Does Duodenitis cause weight loss?
Complications of Duodenitis Black, tarry stool. Severe stomach pain. Fast weight loss. Pain that doesn’t get better.
Does Duodenitis cause malabsorption?
From the clinical point of view, patients with chronic atrophic duodenitis do not show evidence of malabsorption while such phenomena occur consistently, even though in varied form, in celiac disease.
What are the symptoms of microscopic colitis?
Signs and symptoms of microscopic colitis include:
- Chronic watery diarrhea.
- Abdominal pain, cramps or bloating.
- Weight loss.
- Nausea.
- Fecal incontinence.
- Dehydration.
Collagenous sprue (CS) is a rare disease of the small bowel that was first described in 1947 and histologically confirmed in 1970.1,2This disease is characterized by complete atrophy of mucosal villi and excessive subepithelial collagen deposition that may replace the crypts.
Is there a link between collagenous sprue and celiac disease?
Celiac disease has been intimately linked to collagenous sprue and, similar to celiac disease, small bowel ulceration, perforation and lymphoma may complicate the clinical course of collagenous sprue.
Does collagenous sprue cause malabsorption in myotonic dystrophy?
Collagenous sprue as a cause for malabsorption in a patient with myotonic dystrophy: a new association. Am J Gastroenterol. 1988;83:765–766. [PubMed] [Google Scholar]