What are lobules in the liver?
Liver lobules are collections of hepatocytes in a hexagonal shape with the center being a central vein. Within the lobules, the hepatocytes are arranged in cords, and in between the cords is a vascular space with a thin fenestrated endothelium and a discontinuous membrane called a sinusoid.
What is liver Acinus?
The hepatic acinus is the functional unit of the liver. As seen overlayed onto lobules in the diagram below, the acinus consists of an irregular shaped, roughly ellipsoidal mass of hepatocytes aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids.
What type of connective tissue is found in the liver?
The normal liver contains typical connective tissue proteins (collagens, structural glycoproteins and proteoglycans) not only in vessel walls, perivascular areas and in the capsule, but they occur also in small amounts in the parenchyma, mainly in the space of Disse along the sinusoidal walls.
What is the Kupffer cell?
Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.
What is a lobule histology?
As you can observe above, a lobule is a roughly hexagonal arrangement of plates of hepatocytes radiating outward from a central vein (CV) in the center. Central veins are quite prominent and provide an easy means of orientation in sections of liver.
What is Portal area?
Abstract. The portal area is the ‘main entrance’ and one of the two main exits of the liver lobule. Through the main entrance portal and arterial blood reach the liver sinusoids. Through the exit the bile flows towards the duodenum.
What is space of mall?
The periportal space (Latin: spatium periportale), or periportal space of Mall, is a space between the stroma of the portal canal and the outermost hepatocytes in the hepatic lobule, and is thought to be one of the sites where lymph originates in the liver.
What tissues is the liver made up of?
The liver has a thin capsule of dense connective tissue, and a visceral (inferior) layer of peritoneal mesothelium, and is divided into left and right lobes.
Which area of the liver contain strands of connective tissue?
Lobules appear quite clearly in pig liver, which has an envelope of fibrous connective tissue around each lobule. (This tough connective tissue is one reason why pig liver, unlike calf liver or chicken liver, is not a popular menu item.)
What is the histology of the liver?
Liver Histology. The liver is the largest internal organ of the human body, weighing approximately 1.5 kg. Embryologically it develops from the foregut and it spans the upper right and part of left abdominal quadrants. Anatomically the liver consists of four lobes: two larger ones (right and left) and two smaller ones (quadrate and caudate).
Do antidiabetic medications affect histology in non-alcoholic fatty liver disease?
Statins, antidiabetic medications and liver histology in patients with diabetes with non-alcoholic fatty liver disease Several medications used in patients with diabetes are differently associated with NAFLD histology. Statin use is negatively associated, while insulin and sulfonylureas are positively associated with NASH and SF.
What are the roads and houses of the liver?
In the case of the liver, the roads are connective tissue septae which convey vascular and biliary traffic, and the clusters of houses are cord-like arrangements of hepatocytes, the parenchymal cell of the liver.
What is it like to look at a section of liver?
Histology of the Liver. Looking at a section of liver is somewhat reminiscent of looking down out of an airplane at a suburban neighborhood. One sees a very regular, almost monotonous, collection of houses in blocks demarcated by roads, with a gas station or minimart apparent at almost every intersection.