How do you differentiate endocervical and endometrial cancer?
Assessment of hormone receptor expression is most useful for this distinction, as the gastric-type cervical adenocarcinomas are typically ER and PR negative whereas endometrial mucinous adenocarcinomas and endometrioid adenocarcinomas with mucinous differentiation are characteristically hormone receptor positive.
What is endocervical carcinoma?
Endocervical adenocarcinoma is a type of cervical cancer. The tumour develops in the cervix from the glands normally found in the endocervical canal. Most tumours develop from a non-invasive type of cancer called adenocarcinoma in situ (AIS).
What is benign squamous epithelium?
Squamous metaplasia is a benign non-cancerous change (metaplasia) of surfacing lining cells (epithelium) to a squamous morphology.
What is AGC NOS?
Atypical glandular cells on cervical smears are often associated with clinically significant uterine lesions. The frequency and accuracy of AGC-NOS (i.e. atypical glandular cells, not otherwise specified) diagnoses, regardless of the gland cell type or the degree of suspicion, and their outcome were investigated.
What type of cancer is cervical cancer?
The main types of cervical cancers are squamous cell carcinoma and adenocarcinoma. Most (up to 9 out of 10) cervical cancers are squamous cell carcinomas. These cancers develop from cells in the exocervix. Squamous cell carcinomas most often begin in the transformation zone (where the exocervix joins the endocervix).
Is endometrioid carcinoma the same as endometrioid adenocarcinoma?
Types of endometrial cancer Endometrial carcinomas can be divided into different types based on how the cells look under the microscope. (These are called histologic types.) They include: Adenocarcinoma (most endometrial cancers are a type of adenocarcinoma called endometrioid cancer — see below)
How serious is AGC?
Atypical glandular cells (AGC) diagnosis should be immediately followed up with a clinician. There is risk of premalignant lesions in patients diagnosed with AGC is as high as 11%, the risk of endometrial cancer is 3%, and the risk of cervical cancer is 1%. AGC is found in <1% of cervical cytology specimens.
What is AGC Pap smear?
AGC indicates glandular cells on a Pap test that appear abnormal. Glandular cells on a Pap test are usually cells from the cervical canal but may also come from the uterus. Although rare, it is also possible for cervical cancer (rather than precancer) to be detected by a Pap test.